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OBJECTIVE:To investigate the utilization and trend of endocrine therapeutic drugs after breast cancer surgery,and to provide reference for rational drug use in clinic. METHODS:In retrospective study,the data of endocrine therapeutic drugs use in outpatients after breast cancer in a Third Grade Class A Hospital during 2014-2016 was calculated,sorted and analyzed statistically. RESULTS:The age of outpatients receiving endocrine therapy after breast cancer ranged from ＞40 to 60. Among endocrine therapeutic drugs used within 3 years,3 kinds of them were aromatase inhibitor(AI),3 kinds were anti-estrogen and 2 kinds were gonadotropin releasing hormone(GnRH)analogues. The amount of Toremifene citrate tablets(imported)in prescription was much more than the others. The proportion of anti-estrogen drugs alone in prescription was the highest(81.11%). The AI and GnRH analogues were mostly used in drug combination prescription,and commonly combined with anti-osteoporosis drugs. The comsuption sum of endocrine therapeutic drugs was increased year by year,increasing by 52.48% in 2015,40.60% in 2016. The consumption sum of AI ranked the highest proportion among three categories of endocrine drugs(44.71%,48.62%,48.62%,each year respectively). The consumption sum of imported drugs was significantly higher than that of domestic drugs. The consumption sum of Toremifene citrate tablets(imported)increased continuously in 3 years,and took the first place in 2016. The consumption sum of Leuprorelin acetate microspheres for injection(imported)had the largest growth rate when applied to the clinic. Top types in the list of DDC were all imported types;Fulvestrant injection(imported)ranked top 1,and Tamoxifen citrate tablet(domestic) was the bottom of the list. DDDs of endocrine therapeutic drugs also increased year by year,among which Toremifene citrate tablets,Tamoxifen citrate tablets,Anastrozole tablets and Letrozol tablets ranked top 4 places during the 3 years,while Tamoxifen citrate tablets DDDs decreased year by year. B/A values of these drugs were between 0.25 and 9.00. B/A values of domestic varieties were basically more than or equal to 1,of which Tamoxifen citrate tablets was the largest;B/A values of the imported varieties were basically less than or equal to 1. CONCLUSIONS:The consumption sum of endocrine therapeutic drugs after breast cancer surgery increased year by year in 3 years,and DDDs is also increasing year by year. The imported drugs took up the dominant place. Toromiphene citrate tablets had replaced Tamoxifen citrate tablets as the first choice of endocrine therapeutic drugs in the hospital. The frequency of AI and GnRH analogues use had also increased. And the combination of 2 kinds of endocrine therapeutic drugs and endocrine therapeutic drugs combined with anti-osteoporosis drug had become a trend of clinical treatment. The choice of therapeutic drugs should take into account of effectiveness,safety,economics,cost and therapeutic efficacy,so as to guarantee the greatest benefit of the patient.
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Objective: To investigate the application and tendency of carbapenems in the hospitals of Wuhan area.Methods: The application of carbapenems in 34 hospitals of Wuhan area during 2007-2014 was analyzed statistically in terms of consumption sum, DDDs, DDC and so on.Results: The total consumption sum of carbapenems increased year by year.Compared with that in 2007, the total consumption sum increased by 4-fold in 2014.The growing rate of total consumption sum of biapenem was the fastest among various varieties.Since 2009, three injections including meropenem, biapenem and imipenem / cilastatin predominated the market of Wuhan area, followed by faropenem with oral administration.The changing trend of DDDs was basically consistent with the total consumption sum.DDC of all the drugs was relatively high and demonstrated decreasing tendency, and that of biapenem decreased most notably, while still ranked the first place.DDC of meropenem and imipenem/cilastatin both exceeded 400 yuan.The price of faropenem fluctuated notably during 2007-2009, while increased by 2-fold in 2009 (453 yuan) and then remained stable.Conclusion: The special rectification measures show positive impact on the selection of antimicrobial agents in Wuhan area.The drug varieties are proper, while the average daily cost is still high.The government should continue to strengthen the management of antibiotics to ensure the rational use of carbapenems.
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OBJECTIVE:To provide reference for rational drug use in the clinic. METHODS:The calculation was carried out in type,amount and consumption sum of Chinese patent medicines containing Salvia miltiorrhiza in our hospital during 2011-2014. These data were analyzed,classified and sorted by DDDs sequence and the method of pharma-coeconomics with Excel statistically. RESULTS:The consumption sum of Chinese patent medicines containing S. miltiorrhiza took on little changes in our hospital dur-ing 2011-2014,decreasing by 10.52% in 2012 compared to 2011 but increasing by 8.49% in 2013 compared to 2012. The order of DDDs kept stable,indicating that Chinese patent medicines containing S. miltiorrhiza were used frequently in 4 year. The order of consumption sum also kept stable relatively. CONCLUSIONS:The utilization of Chinese patent medicines containing S. miltiorrhi-za in our hospital is rational. Those with suitable prices and proved efficacy take a great share in the clinical application.
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Objective To analyze the utilization of antibiotics for special use in our hospital in order to provide references for rational use antibiotics in clinic .Methods The utilization of antibiotics for special use in our hospital from 2010 to 2011 was analyzed with defined daily dose (DDD), consumption sum, DDC, DDDs and B/A as indexes.Results 72.22%of antibiotics for special use had been used in our hospital , main in injection .The changes of consumption sum , DDDs and proportion , DDC of antibiotics for spe-cial use varied from each other .The ratio of B to A of antibiotics for special use was in a range of 0.29~9.00.Conclusion The per-formance of stratified management of antibiotics did not implement exactly .It was necessary to strictly control the introduction , intensify education of medication and rigorously implement the performance of stratified management of antibiotics .
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@#Objective To investigate the drug utilization of inpatients in neurological rehabilitation department in our hospital. Methods The statistics data of neurological rehabilitation treatment drugs in our hospital from 2008 to 2010 were statistically analyzed, including drug type, the amount of medication, defined daily doses (DDDs) and average defined daily cost (DDC). Results The amount of medication and DDDs increased year by year, the top 3 amount of sales drugs were neurological function and nootropics drugs, the top 3 for DDDs were the promotion of brain metabolism and nootropics drugs. Methylcobalamin tablets, nifedipine and aspirin enteric-coated tablet were in low DDC. Conclusion The use of drug in neurological rehabilitation department in our hospital was in line with the basic features of neuro-rehabilitation specialist.
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OBJECTIVE:To investigate the drug utilization for osteoarthritis in VIP clinic of our hospital. METHODS:The prescriptions of Chinese patent medicine and western medicines for osteoarthritis patients in VIP clinic in our hospital in the first half year from 2007 and 2009 were analyzed statistically by using DDDs analytical method. RESULTS:Among all the western medicines,analgesic and antiphlogistic categories were predominantly used,followed by Sodium Alendronate and Calcitonin (bone resorption inhibitors); the categories that can tonify kidney,invigorate bone,fight against rheumatism or hyperostosis took the lead among all the Chinese patent medicines. CONCLUSION:The drug utilization for osteoarthritis in VIP clinic of our hospital is rational with confirmed efficacy. The combined treatment of Chinese patent medicine and western medicine is an effective therapy worthy of further exploration.
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OBJECTIVE:To analyze the utilization status and developing trend of drugs in Chengdu area. METHODS:Data regarding the drug variety,consumption quantity and sum of money in 16 hospitals of Chengdu area between 2001 and 2006 were analyzed retrospectively. RESULTS:The drug consumption sum in 16 Hospitals of Chengdu area from 2001 to 2006 increased by 19.56%,27.19%,17.84%,15.08% and 10.40%,respectively,assuming an downtrend. Among the top 14 chief drug categories on the list of consumption sum,the sequence of anti-infective agents,cardiovascular agents,antineoplastic agents and nervous system agents experienced no obvious changes. CONCLUSION:The drug utilization in Chengdu area tends to be rational and standard.
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OBJECTIVE:To evaluate the role and function of hospital preparations.METHODS:A retrospective analysis was conducted on the utilization of hospital preparations in our hospital from July 1,2005 to June 30,2006.RESULTS:A total of 158 kinds of hospital preparations were used in our hospital,with their sales value totaling RMB 10.025 3 million,representing 1.13% of total drug sales.The top 10 selling hospital preparations accounted for 72.2% of all hospital preparations in sales value.A difference was seen in use of hospital preparations by outpatient and inpatient departments.CONCLUSIONS:Hospital preparations are indispensable for routine diagnosis and medication despite their small proportion in sales value of total drugs.
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OBJECTIVE:To evaluate the drug utilization in nationwide sample hospitals so as to provide information for the production, management and utilization of drugs. METHODS: The drug utilization data in nationwide 690 hospitals during the period 2005 ～2006 were analyzed statistically. RESULTS & CONCLUSION: Anti-infective drugs, cardiovascular drugs, biological products and biochemical drugs have been ranking among the first 3 places in consumption, but their consumption sum showed a downward trend. The consumption sum of anti-tumor drugs, Chinese formulated products, digestive system drugs, and respiratory system drugs showed an upward trend. The top 20 drugs on the list of consumption sum were mainly antibiotics. The consumption quantity and consumption sum of anti-tumor drugs showed an upward trend. Of the top 10 manufacturers in terms of consumption sum, the imported manufacturers took a small proportion while the joint venture took a higher proportion.
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OBJECTIVE:To analyze the utilization of drugs in children with ventricular septal defect(VSD) undergoing operation.METHODS:The medical orders of 120 VSD children patients in our hospital in 2005 were analyzed retrospectively.RESULTS:The per capita drug cost was(3 067.20? 325.04) yuan,accounting for 9.52% of the total medical cost.Circulatory system drugs and antibiotics were the chief categories.Leading the first 3 places in terms of DDDs were cefuroxime,vecuronium bromide and furosemide,respectively.CONCUSION:The drug cost for VSD children patients was relatively low and reasonable.
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OBJECTIVE:To evaluate the status quo and the trend of the clinical utilization of antineoplastic assistant drugs in our hospital.METHODS:The utilization of antineoplastic assistant drugs in our hospital between 2001 and 2006 was analyzed statistically in respect of the drug kinds,dosage form,consumption sum and DDDs etc.RESULTS:Both the number of kinds and the consumption sum of antineoplastic assistant drugs increased year on year from 2002 to 2006(except in 2001). Chinese traditional drugs,western medicines and biological products were the top three categories of all the antineoplastic assistant drugs used in our hospital.In terms of consumption sum,Chinese traditional drugs had dominated the first place over the five consecutive years.In terms of DDDs,traditional Chinese antineoplastic drugs,other kinds of antineoplastic adjuvant drugs,antivomit drugs,Shengbaiyao(increasing the number of leucocytes) took the lead.Of all the antineoplastic assistant drugs used,domestic injections took the lead.CONCLUSION:The utilization of the antineoplastic assistant drugs in our hospital was rational on the whole yet the consumption of which increased rapidly,thus strengthened management on which is still needed.
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OBJECTIVE:To investigate the status quo of the use of Chinese patent medicines in our hospital and to put forward the coping strategies.METHODS:The data about the consumption of Chinese patent medicines in our hospital during the period of 2002～2006 obtained from medical information platform were analyzed in respect of consumption sum,DDDs,and DDC using the method of DDDs sequence and the method in pharmacoeconomics.RESULTS:The use of Chinese patent medicines in our hospital during 2002～2006 took on an obvious rising trend.CONCLUSION:The utilization of Chinese patent medicines in our hospital is rational basically.The Chinese patent medicines with suitable prices and proved efficacy take a great share in the clinical application.However,there are still some problems remain to be standardized.
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OBJECTIVE:To evaluate the utilization of human serum albumin in a hospital.METHODS:The utilization of human serum albumin in a hospital in the first quarter of 2006 was reviewed analytically using hospital computer database system.RESULTS:Human serum albumin was used in 55 departments for 17 categories of diseases,mainly for critical patients,with a common individual consumption quantity ranged from 10 g to 20 g.Most(51.10%) of the patients used this drug on account of hypoproteinemia,and most of them had a baseline serum albumin level at 21～30 g?L-1 before using human serum albumin.CONCLUSION:Human serum albumin was used extensively in the hospital.But its use is sometimes irrational because some physicians didn't familiarize the real indications for using human albumin,which should be intervened urgently.